Mice with altered α-actinin-4 expression have distinct morphologic patterns of glomerular disease
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چکیده
منابع مشابه
Podocyte Injury Associated with Mutant α-Actinin-4
Focal segmental glomerulosclerosis (FSGS) is an important cause of proteinuria and nephrotic syndrome in humans. The pathogenesis of FSGS may be associated with glomerular visceral epithelial cell (GEC; podocyte) injury, leading to apoptosis, detachment, and "podocytopenia", followed by glomerulosclerosis. Mutations in α-actinin-4 are associated with FSGS in humans. In cultured GECs, α-actinin-...
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Savita V. Dandapani, Hikaru Sugimoto, Benjamin D. Matthews, Robert J. Kolb, Sumita Sinha Robert E. Gerszten, Jing Zhou, Donald E. Ingber, Raghu Kalluri, Martin R. Pollak Department of Genetics, Harvard Medical School, Boston, MA, Renal Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA Division of Matrix Biology, Beth Israel Deaconess Medical C...
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Filamentous actin and associated actin binding proteins play an essential role in governing the mechanical properties of eukaryotic cells. They can also play a critical role in disease; for example, mutations in α-actinin-4 (Actn4), a dynamic actin cross-linking protein, cause proteinuric disease in humans and mice. Amino acid substitutions strongly affect the binding affinity and protein struc...
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Ribosome-inactivating proteins (RIPs, EC 3.2.2.22) are potent naturally occurring toxins found in numerous and diverse plant species. The maize RIP is unusual among the plant RIPs because it is synthesized as an inactive precursor (also known as maize proRIP1 or b-32). The proenzyme undergoes proteolytic activation that results in the removal of the NH(2)-terminal, the COOH-terminal, and intern...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2008
ISSN: 0085-2538
DOI: 10.1038/sj.ki.5002751